Milk is one among the major foods consumed worldwide. Beyond its nutritional value, it is economically important since there are more than 6 billion consumers for milk and milk products. The quality of milk determined by its components, microbial quality and now drug residues too. Antimicrobials used in animals as therapeutic, prophylactic and sometimes used as feed additives which causes drug residue in milk. If antibiotics are present beyond their maximum residue level (MRL), there will be health damage

to the consumer ranging from allergic reactions to bacterial resistance. Some of the studies reported that the excessive use of antibiotics in animals to the appearance of super bacteria in humans. Above 60,000 tons of antibiotics are being used in livestock worldwide which is double the amount compared to human. Many times antibiotics are released unaltered, with full potential of antimicrobial activity. Methodologies or protocols to mitigate the antimicrobial residue in milk are detailed in this review. Since

this antimicrobial residue (AMR) problem is worldwide threat, awareness among the milk producers and consumers must be created. Judicious usage methods of antimicrobials are detailed which must be entertained by the veterinarians. The modern tools with high sensitivity for quick and accurate detection of AMR at field level viz., CG-MS (gas chromatography coupled to mass spectroscopy), HPLC (High performance Liquid Chromatography), FT-NIR (Fourier Transform Near Infrared Spectroscopy) were discussed with their usage and drawbacks. Existing ethnoveterinary medicines to replace the antibiotics in the treatment of ailing dairy animals are reviewed and suggested the adoption practices for documented and established herbal practices. Alternating the antimicrobials novel bio-controlling agents like bacteriophages against antimicrobial resistant Staphylococcus may be intervened and various bio-controlling agents are discussed. To reduce the antibiotic usage, proper bio security measures are to be followed for avoiding the infections. Various biosecurity measures of dairy farming are given in this review, to be implemented by small, medium and large scale farmers. It is suggested that one of the major ways and means to reduce the AMR in milk is not procuring the milk with the contaminant of AMR. Milk of the animals which are in the treatment or withholding period of the antibiotic after treatment should not be included in the pooled milk. Policy makers should take the strong decision for procurement of milk to reduce the AMR in milk.