The aim of this clinical study over 310 patients is to evaluate the success rate using Chlorhexidine (CHX) as a

cleaning solution and lubricant during the endodontic treatment, compared with sodium hypochlorite (NaOCl). Materials and Methods: Group A consisted of 169 teeth, from which 78 were in a pulpitis stadium and 69 in a gangrenous stage. They were treated with CHX solution during endodontic dental procedures. The Group B consisted of 76 pulpits and 65 gangrenous teeth irrigated with NaOCl. Biostatistical analyzes using t-test with IBM SPSS 22.0 were applied to validate the results for P < 0.05. Results: The results show a success rate of 97% and a treatment success rate 3.5 times higher when using CHX in a much shorter time of treatment. 38.5% of cases were completed in the fi rst session of treatment, 42.5% in the second session and only 19% of cases being completed in the third treatment session. In Group A was obtained 100% success in pulpitis and 94.5% from gangrene was successfully cured, compared with 88% average success rate in Group B (6.5% failure rate in the pulp disease and 24% in gangrene). Conclusions: The advantages of using CHX instead

of NaOCl in endodontic treatment proved by this study, in conjunction with results published since the early 80’s, show the supremacy of CHX solution in endodontic treatment.